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Cell Mol Immunol. 2008 Feb;5(1):9-21. doi: 10.1038/cmi.2008.2.

The classical and regulatory functions of C1q in immunity and autoimmunity.

Author information

1
Department of Microbiology, Yong Loo Lin School of Medicine and 2NUS Immunology Program, National University of Singapore, Blk MD4, 5 Science Drive 2, Singapore 117597. miclujh@nus.edu.sg

Abstract

A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes, opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation, C1q also regulates cell differentiation, adhesion, migration, activation and survival. C1q deficiency is associated with autoimmunity as well as increased susceptibility to infections. In this article, we discuss the basic properties of C1q, its expression, and classical and regulatory functions.

PMID:
18318990
PMCID:
PMC4652917
DOI:
10.1038/cmi.2008.2
[Indexed for MEDLINE]
Free PMC Article

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