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Cancer Chemother Pharmacol. 2008 May;61(6):903-9. doi: 10.1007/s00280-008-0711-0. Epub 2008 Mar 4.

Prevention of cisplatin nephrotoxicity: state of the art and recommendations from the European Society of Clinical Pharmacy Special Interest Group on Cancer Care.

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ICAR, Department of Nephrology, Hôpital Pitié-Salpêtrière, 83 boulevard de l'Hôpital, 75013 Paris, France.


Antineoplastic drugs used in the treatment of cancers present with variable renal tolerance profiles. Among drugs with a potential for renal toxicity, platinum salts, and especially cisplatin is a well-known agent that may induce acute and chronic renal failure. The mechanisms of its renal toxicity and the means of its prevention are presented in this article which represent the Clinical Recommendation from the Special Interest Group on Cancer Care of the European Society of Clinical Pharmacy (ESCP).

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