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AIDS. 2008 Mar 12;22(5):655-8. doi: 10.1097/QAD.0b013e3282f4de23.

Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands.

Author information

1
Partners AIDS Research Center, Massachusetts General Hospital, Division of AIDS, Harvard Medical School, Boston, Massachusetts, USA.

Abstract

Increased PD-L1 expression has been reported in HIV-1-infected individuals, but the mechanisms leading to PD-L1 upregulation remain to be elucidated. Here we demonstrate that HIV-1-derived Toll-like receptor (TLR)7/8 ligands can induce MyD88-dependent upregulation of PD-L1 on plasmacytoid dendritic cells, myeloidic dendritic cells and monocytes. These data suggest a mechanism through which HIV-1-derived TLR ligands might contribute to the functional impairment of virus-specific PD-1-positive T cells by inducing the upregulation of PD-L1 on antigen-presenting cells.

PMID:
18317010
PMCID:
PMC2810187
DOI:
10.1097/QAD.0b013e3282f4de23
[Indexed for MEDLINE]
Free PMC Article

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