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AIDS. 2008 Mar 12;22(5):637-42. doi: 10.1097/QAD.0b013e3282f4de10.

Effects of antiretroviral therapy on semen quality.

Author information

1
Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands. e.vanleeuwen@amc.uva.nl

Abstract

OBJECTIVE:

To evaluate the effect of combination antiretroviral therapy (cART) on semen quality.

DESIGN:

A longitudinal cohort study.

SETTING:

The HIV outpatient clinic of the Academic Medical Centre in Amsterdam, the Netherlands.

SUBJECTS:

A cohort of 34 male patients with different estimated duration of HIV-1 infection, who were about to start various combinations of cART.

INTERVENTION(S):

Blood and semen analyses before the start of cART and 4, 12, 24, 36 and 48 weeks thereafter.

MAIN OUTCOME MEASURE(S):

We examined the effect of cART on semen parameters by a repeated measurements procedure using a mixed-effects model.

RESULTS:

The median period of follow up was 48 weeks (interquartile range 33-52 weeks). Five patients used thymidine analogue-containing cART, 23 used tenofovir-based cART, six used other regimens. At all timepoints the percentage of progressively motile spermatozoa was low according to WHO criteria, and it decreased significantly from 28 to 17% during follow-up (P = 0.02). All other semen parameters were in the normal range and remained stable.

CONCLUSION:

cART negatively affected the percentage of progressively motile spermatozoa. Whether this reduced motility affects the chances of fathering a child or leads to an increased need for artificial reproductive techniques is at present unknown.

PMID:
18317005
DOI:
10.1097/QAD.0b013e3282f4de10
[Indexed for MEDLINE]

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