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Pediatr Infect Dis J. 2008 Apr;27(4):357-8. doi: 10.1097/INF.0b013e3181629a55.

Prevalence of ceftriaxone-induced red blood cell antibodies in pediatric patients with sickle cell disease and human immunodeficiency virus infection.

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  • 1Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston, MA 02118, USA. kq@bu.edu

Abstract

Ceftriaxone can be associated with catastrophic immune hemolysis in pediatric patients, particularly those with underlying diseases such as sickle cell disease and human immunodeficiency virus infection. We designed a study to screen for ceftriaxone-induced RBC antibodies in these 2 pediatric populations. The prevalence of anticeftriaxone antibody was 12.5% (8 of 64). Two of these 8 patients with the antibody experienced hemolysis; 1 case was fatal.

PMID:
18316983
DOI:
10.1097/INF.0b013e3181629a55
[PubMed - indexed for MEDLINE]
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