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Aliment Pharmacol Ther. 2008 May;27(10):971-9. doi: 10.1111/j.1365-2036.2008.03664.x. Epub 2008 Feb 28.

Dysphagia: epidemiology, risk factors and impact on quality of life--a population-based study.

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1
School of Public Health, The University of Sydney, Sydney, NSW, Australia. geslick@hsph.harvard.edu

Abstract

BACKGROUND:

Data on the population epidemiology of dysphagia are scarce. Little is known about the prevalence, risk factors and impact on quality of life of dysphagia in the general community.

AIM:

To determine the magnitude and impact of dysphagia in the general community.

METHODS:

A random sample of 1000 individuals of Sydney, Australia, were mailed a validated self-report questionnaire to assess dysphagia. Measured were dysphagia symptoms, potential mechanisms, risk factors, psychological disorders, quality of life and demographics.

RESULTS:

The response rate of included subjects (n = 926) was 73% (n = 672). Dysphagia ever was reported by 16% (n = 110). Multiple logistic regression analysis found that odynophagia was independently associated with gastro-oesophageal reflux disease (GERD) (OR = 3.41, 95% CI: 1.16-10.04). Intermittent dysphagia was independently associated with GERD (OR = 2.96, 95% CI: 1.76-4.98) and anxiety (OR = 1.09, 95% CI: 1.01-1.19). The presence of progressive dysphagia was independently associated with depression (OR = 1.34, 95% CI: 1.07-1.67). Progressive dysphagia was independently associated with reduced 'general health' (OR = 0.95, 95% CI: 0.90-0.99), while intermittent dysphagia was associated with a reduction in the 'role physical' subscale (OR = 0.98, 95% CI: 0.97-0.99).

CONCLUSIONS:

Dysphagia is remarkably common in the general population. GERD is a risk factor for dysphagia as well as odynophagia. Intermittent dysphagia was associated with anxiety, while progressive dysphagia was associated with depression.

[Indexed for MEDLINE]
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