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J Biomed Opt. 2008 Jan-Feb;13(1):014013. doi: 10.1117/1.2841024.

Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry.

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  • 1University of Tsukuba, Computational Optics Group, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan.


Phase retardation of in vivo human retinal nerve fiber layer (RNFL) is quantitatively measured by two methods--polarization-sensitive spectral-domain optical coherence tomography (PS-SD-OCT) and scanning laser polarimetry (SLP). An en face cumulative phase retardation map is calculated from the three-dimensional (3-D) phase retardation volume of healthy and glaucomatous eyes measured by PS-SD-OCT. It is shown that the phase retardation curves around the optic nerve head measured by PS-SD-OCT and SLP have similar values except near the retinal blood vessels. PS-SD-OCT can measure the cumulative phase retardation of RNFL as well as SLP, which will allow the evaluation of RNFL for glaucomatous eyes.

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