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J Biomed Opt. 2008 Jan-Feb;13(1):010501. doi: 10.1117/1.2839043.

In vivo confocal and multiphoton microendoscopy.

Author information

1
Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 50 Blossom St., BAR 818, Boston, Massachusetts 02114, USA.

Abstract

The ability to conduct high-resolution fluorescence imaging in internal organs of small animal models in situ and over time can make a significant impact in biomedical research. Toward this goal, we developed a real-time confocal and multiphoton endoscopic imaging system. Using 1-mm-diameter endoscopes based on gradient index lenses, we demonstrate video-rate multicolor multimodal imaging with cellular resolution in live mice.

PMID:
18315346
PMCID:
PMC2752311
DOI:
10.1117/1.2839043
[Indexed for MEDLINE]
Free PMC Article
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