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J Med Chem. 2008 Mar 27;51(6):1530-3. doi: 10.1021/jm701321p. Epub 2008 Mar 4.

Cytotoxic simplified tubulysin analogues.

Author information

1
Department of Medicinal Chemistry. 308 Harvard Street SE, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

An efficient route for the synthesis of the tubulysin family of antimitotic peptides was developed. Simplified tubulysin analogues were synthesized to define the minimum pharmacophore required for cytotoxicity. Simplified tubulysin analogues retain significant cytotoxicity and reveal important preliminary structure-activity relationships.

PMID:
18314944
DOI:
10.1021/jm701321p
[Indexed for MEDLINE]

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