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Virology. 2008 May 10;374(2):229-33. doi: 10.1016/j.virol.2008.01.029. Epub 2008 Mar 7.

Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses.

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1
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, USA.

Abstract

Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites.

PMID:
18314154
PMCID:
PMC2441482
DOI:
10.1016/j.virol.2008.01.029
[Indexed for MEDLINE]
Free PMC Article

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