Send to

Choose Destination
Gastroenterol Clin North Am. 2008 Mar;37(1):47-72, vi. doi: 10.1016/j.gtc.2007.12.006.

Syndromic colon cancer: lynch syndrome and familial adenomatous polyposis.

Author information

Division of Gastroenterology, Department of Medicine, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA.


Colon cancer, the third leading cause of mortality from cancer in the United States, afflicts about 150,000 patients annually. More than 10% of these patients exhibit familial clustering. The most common and well characterized of these familial colon cancer syndromes is hereditary nonpolyposis colon cancer syndrome (Lynch syndrome), which accounts for about 2% to 3% of all cases of colon cancer in the United States. We review the current knowledge of familial cancer syndromes, with an emphasis on Lynch syndrome and familial adenomatous polyposis.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center