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Mol Cell. 2008 Feb 29;29(4):409-10. doi: 10.1016/j.molcel.2008.02.005.

A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.

Author information

1
Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.

Abstract

DRP1, a member of the dynamin family of large GTPases, mediates mitochondrial fission. In a recent issue of Developmental Cell, Cassidy-Stone et al. (2008) identified mdivi-1, a new DRP1 inhibitor that prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis.

PMID:
18313377
DOI:
10.1016/j.molcel.2008.02.005
[Indexed for MEDLINE]
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