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Bioorg Med Chem. 2008 Apr 1;16(7):3580-6. doi: 10.1016/j.bmc.2008.02.030. Epub 2008 Feb 14.

Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme.

Author information

1
R&D Center, AmorePacific Corporation, 314-1 Bora-Dong, Giheung-Gu, Yongin, Gyeonggi 446-729, Republic of Korea.

Abstract

Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD) is an effectual therapeutic target for metabolic disorders, including obesity and diabetes. In this study, we used in silico and conventional screening approaches to identify putative inhibitors of G6PD and found that gallated catechins (EGCG, GCG, ECG, CG), but not ungallated catechins (ECG, GC, EC, C), were NADP(+)-competitive inhibitors of G6PD and other enzymes that employ NADP(+) as a coenzyme, such as IDH and 6PGD.

PMID:
18313308
DOI:
10.1016/j.bmc.2008.02.030
[Indexed for MEDLINE]

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