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Cell Host Microbe. 2008 Feb 14;3(2):59-61. doi: 10.1016/j.chom.2008.01.005.

Type I interferon response to cytomegalovirus infection: the kick-start.

Author information

1
Department of Human Genetics, McGill University, Montreal, Quebec H3A 1B1, Canada.

Abstract

Host responses to cytomegalovirus infection include initial early production of alpha and beta interferons, also called type I interferons, which are elicited directly by viral products via Toll-like receptors. New data indicate that, preceding these events, an earlier critical type I interferon elicited in primary infected stromal cells via the lymphotoxin beta receptor system and mediated by B cells is necessary to kick-start an efficient antiviral response.

PMID:
18312838
DOI:
10.1016/j.chom.2008.01.005
[Indexed for MEDLINE]
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