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Nat Chem Biol. 2008 Apr;4(4):238-40. doi: 10.1038/nchembio.75. Epub 2008 Mar 2.

Synthetic GPI array to study antitoxic malaria response.

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1
Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland.

Abstract

Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.

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PMID:
18311131
DOI:
10.1038/nchembio.75
[Indexed for MEDLINE]
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