Approaches to dimensionality reduction in proteomic biomarker studies

Brief Bioinform. 2008 Mar;9(2):102-18. doi: 10.1093/bib/bbn005. Epub 2008 Feb 29.

Abstract

Mass-spectra based proteomic profiles have received widespread attention as potential tools for biomarker discovery and early disease diagnosis. A major data-analytical problem involved is the extremely high dimensionality (i.e. number of features or variables) of proteomic data, in particular when the sample size is small. This article reviews dimensionality reduction methods that have been used in proteomic biomarker studies. It then focuses on the problem of selecting the most appropriate method for a specific task or dataset, and proposes method combination as a potential alternative to single-method selection. Finally, it points out the potential of novel dimension reduction techniques, in particular those that incorporate domain knowledge through the use of informative priors or causal inference.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Biomarkers / analysis*
  • Electronic Data Processing* / instrumentation
  • Electronic Data Processing* / methods
  • Mass Spectrometry / methods
  • Proteome / analysis
  • Proteomics / methods*
  • Research Design
  • Research* / instrumentation

Substances

  • Biomarkers
  • Proteome