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Arch Orthop Trauma Surg. 2009 Feb;129(2):281-6. doi: 10.1007/s00402-008-0603-0. Epub 2008 Feb 29.

High-dose vitamin C supplementation accelerates the Achilles tendon healing in healthy rats.

Author information

1
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Abstract

INTRODUCTION:

This experimental study was performed to assess, whether or not, vitamin C, required during the collagen synthesis, would influence the Achilles tendon healing in a healthy rat model.

MATERIALS AND METHODS:

The right Achilles tendons of 42 healthy female Wistar Albino rats were completely ruptured. The rats were randomly divided into the vitamin C and control groups and both groups included third, tenth and twenty-first day subgroups. One hundred and fifty milligrams (1.5 cc) of vitamin C and 1.5 cc % 0.9 NaCl were injected once for every 2 days for the vitamin C and control groups, respectively. Qualitative and quantitative microscopic comparisons of the repair tissues of both groups were made on the mentioned days.

RESULTS:

Angiogenesis was more evident on the third day in the vitamin C group. There was a significant difference between the control and vitamin C groups regarding the type I collagen production on the tenth day. The structure of the repair tissue was almost in the form of regular dense connective tissue at the end of twenty-first day in the vitamin C group. Mean collagen fiber diameter was considerably higher, and the number of active fibroblasts in the repair tissue was slightly elevated in the vitamin C group during the entire healing process.

CONCLUSION:

High-dose vitamin C supplementation once for every 2 days has stimulating effects on the Achilles tendon healing because of early angiogenesis and increased collagen synthesis in a healthy rat model. Further studies are needed to make clear the mentioned encouraging effects of the vitamin C on the Achilles tendon healing.

PMID:
18309503
DOI:
10.1007/s00402-008-0603-0
[Indexed for MEDLINE]

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