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Kidney Int. 2008 Mar;73(6):671-3. doi: 10.1038/sj.ki.5002798.

It's not all about nephrin.

Author information

1
Mount Sinai School of Medicine, Department of Developmental and Regenerative Biology, New York, New York 10029, USA. matias.simons@mssm.edu

Abstract

Mutations in the NPHS1 gene cause congenital nephrotic syndrome of the Finnish type. The gene product nephrin is a structural component of the glomerular slit diaphragm formed by neighboring podocytes. Nephrin has also been suggested to be involved in signaling processes that are important for podocyte survival and differentiation. A new study by Doné et al. reports that the absence of nephrin leads to the lack of slit diaphragms but does not affect podocyte apoptosis and gene expression patterns.

PMID:
18309348
DOI:
10.1038/sj.ki.5002798
[Indexed for MEDLINE]
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