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Cytokine. 2008 May;42(2):145-151. doi: 10.1016/j.cyto.2008.01.006. Epub 2008 Mar 4.

LPS/TLR4 signal transduction pathway.

Author information

1
The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1.
2
The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1. Electronic address: wyeh38@gmail.com.
3
The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1; Department of Immunology, University of Toronto, Toronto, Ont., Canada M5S1A8. Electronic address: pohashi@uhnres.utoronto.ca.

Abstract

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.

PMID:
18304834
DOI:
10.1016/j.cyto.2008.01.006
[Indexed for MEDLINE]

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