Send to

Choose Destination
See comment in PubMed Commons below
Neuroscience. 2009 Jan 12;158(1):45-54. doi: 10.1016/j.neuroscience.2007.12.046. Epub 2008 Jan 18.

Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins.

Author information

  • 1Department of Biochemistry I-Receptor Biochemistry, Building NC, Room 6/171, Ruhr University Bochum, Universit√§tsstr. 150, D-44780 Bochum, Germany.


The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous trafficking and scaffolding proteins. Participating in the delivery and synaptic localization of AMPA receptors is a recently discovered protein family named transmembrane AMPA receptor regulatory proteins (TARPs). In addition to their function in trafficking, TARPs alter the biophysical properties of AMPA receptors in remarkable ways and thus contribute significantly to the functional plasticity of the synapse. The study of TARP-mediated functional plasticity of AMPA receptors, which has emerged only recently as a hot new field, promises to yield valuable insight into the regulation of neuronal communication.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center