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Neuron. 2008 Feb 28;57(4):477-9. doi: 10.1016/j.neuron.2008.02.004.

Ama "zinc" link between TrkB transactivation and synaptic plasticity.

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1
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892-3714, USA.

Abstract

While Trk receptors can be activated in a neurotrophin-independent manner through "transactivation" by GPCR ligands, its physiological significance in the brain remains unknown. Huang et al. have now identified a novel mechanism of TrkB transactivation. They show that zinc ions can transactivate TrkB independent of neurotrophins and that such a transactivation is important for mossy fiber long-term potentiation (LTP).

PMID:
18304477
DOI:
10.1016/j.neuron.2008.02.004
[Indexed for MEDLINE]
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