Mitogen-activated protein kinase pathway may closely associated with cell growth, differentiation and apoptosis, it may play an important role in cell death. With growing evidences from in vitro test, recently it demonstrated that the MAPK play a key role in the reproductive toxicity induced organochlorine pesticides and also showed that the products of Reactive Oxygen Species (ROS) induced organochlorine pesticides in these process. The relationship between MAPK and their activation results in apoptosis induced organochlorine pesticides, for further clarification of the mechanism of male reproductive toxicity induced organochlorine pesticides.