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J Occup Environ Med. 2008 Feb;50(2):182-9. doi: 10.1097/JOM.0b013e31815cf6cc.

Urinary 8-isoprostane and 8-OHdG concentrations in boilermakers with welding exposure.

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1
Department of Environmental Health, Harvard School of Public Health, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

Abstract

OBJECTIVE:

To investigate the association of exposure to fine particulate matter (PM2.5) with DNA damage and oxidative stress in boilermakers exposed to welding fumes.

METHODS:

Forty-one workers were monitored over 24 hours during which baseline, postshift, bedtime, and next morning measurements were collected. Twenty-two workers participated as controls.

RESULTS:

Linear regression was used to model pairwise change in u-8-isoprostane and u-8-OHdG: pre- to postshift, preshift to bedtime, postshift to bedtime, and postshift to next morning. In the models, pre- to postshift change in 8-OHdG was statistically significant, whereas postshift to bedtime change in 8-isoprostane showed an unexpected inverse relationship with PM2.5.

CONCLUSIONS:

Acute welding exposure is associated with a postshift blunting of systemic inflammation in chronically exposed boilermakers, as measured by 8-isoprostane. The level of oxidative DNA damage as measured by 8-OHdG is less clear.

PMID:
18301175
DOI:
10.1097/JOM.0b013e31815cf6cc
[Indexed for MEDLINE]
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