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Int Rev Immunol. 2008 Jan-Apr;27(1-2):79-92. doi: 10.1080/08830180701883240.

Immunobiology of stiff-person syndrome.

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1
Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA. RRaju@uab.edu

Abstract

The two possibilities to explain the pathogenic basis of stiff-person syndrome (SPS) are intrathecal sensitization of GAD65-reactive CD4+T cells and synthesis of GAD65-specific autoantibodies within the CNS [Rakocevic et al., Arch. Neurol. 61: 902-904, 2004]; and peripheral antigen sensitization followed by CNS antigen recognition by autoantibodies that cross the blood-brain barrier. Antigen-specific CD4+ T cells are essential for the generation of high-affinity autoantibodies [Lanzavecchia, Nature 314: 537-539, 1985], but there is no evidence of cellular infiltration in the CNS of SPS patients [Warich-Kirches et al., Clin. Neuropathol. 16: 214-219, 1997; Ishizawa et al., Acta Neuropathol.(Berl) 97: 63-70, 1999]. This review discusses the possible role of autoantibodies and autoreactive T cells specific to neuronal antigens in SPS pathogenesis.

PMID:
18300057
DOI:
10.1080/08830180701883240
[Indexed for MEDLINE]
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