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Folia Microbiol (Praha). 2007;52(5):479-83.

Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae.

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Department of Cell and Developmental Biology, Pasteur Institute-Cenci Bolognetti Foundation, University of Rome La Sapienza, 5 00185 Rome, Italy.


Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed. MDM30 and DNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast, YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes. FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.

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