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Cell. 2008 Feb 22;132(4):532-6. doi: 10.1016/j.cell.2008.02.006.

Capturing pluripotency.

Author information

1
Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QR, UK.

Abstract

In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification.

PMID:
18295569
PMCID:
PMC2427053
DOI:
10.1016/j.cell.2008.02.006
[Indexed for MEDLINE]
Free PMC Article

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