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Bioorg Med Chem Lett. 2008 Mar 15;18(6):1931-8. doi: 10.1016/j.bmcl.2008.01.125. Epub 2008 Feb 7.

Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.

Author information

1
Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, CA 92130, USA.

Abstract

Based on 3-phenylpropionamides, a series of 3-arylpyrrolidine-2-carboxamide derivatives was designed and synthesized to study the effect of cyclizations as melanocortin-4 receptor ligands. It was found that the 2R,3R-pyrrolidine isomer possessed the most potent affinity among the four stereoisomers.

PMID:
18294847
DOI:
10.1016/j.bmcl.2008.01.125
[Indexed for MEDLINE]

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