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Gastrointest Endosc. 2008 Mar;67(3):458-66. doi: 10.1016/j.gie.2007.07.028.

A prospective crossover study comparing secretin-stimulated endoscopic and Dreiling tube pancreatic function testing in patients evaluated for chronic pancreatitis.

Author information

1
Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Abstract

BACKGROUND:

Direct pancreatic function tests (PFT) are conventionally performed with use of double-lumen "Dreiling" collection tubes. We have developed an endoscopic collection method (ePFT) that eases the performance of these tests.

OBJECTIVE:

Our aim was to compare the bicarbonate results obtained from the secretin ePFT and Dreiling PFT methods in patients evaluated for chronic pancreatitis.

DESIGN:

A prospective crossover design was used to compare the PFT methods.

SETTING:

Tertiary care referral center.

PATIENTS AND INTERVENTIONS:

Twenty-four patients undergoing an evaluation for chronic pancreatitis underwent the secretin-stimulated ePFT and Dreiling PFT methods on separate days.

MAIN OUTCOME MEASUREMENTS:

Duodenal fluid bicarbonate concentrations and estimated bicarbonate outputs were compared.

RESULTS:

The mean difference in peak bicarbonate concentration (Dreiling PFT minus ePFT) was 7 mEq/L (SD 20) and not statistically significant (P = .11). A good correlation in peak bicarbonate concentrations (r = 0.74, 95% CI, 0.48-0.88) and estimated bicarbonate output (r = 0.78, 95% CI, 0.54-0.90) was observed between the two PFT methods.

LIMITATION:

The sensitivities and specificities of the secretin ePFT and Dreiling PFT could not be compared because of the lack of a histologic gold standard.

CONCLUSION:

The secretin ePFT yields results similar to those of the Dreiling PFT in patients evaluated for chronic pancreatitis.

PMID:
18294508
DOI:
10.1016/j.gie.2007.07.028
[Indexed for MEDLINE]

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