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Cephalalgia. 2008 May;28(5):484-95. doi: 10.1111/j.1468-2982.2008.01555.x. Epub 2008 Feb 20.

Guidelines for controlled trials of prophylactic treatment of chronic migraine in adults.

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Jefferson Headache Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA. [corrected]

Erratum in

  • Cephalalgia. 2008 Jun;28(6):679.


In 1991 the Clinical Trials Subcommittee of the International Headache Society (IHS) developed and published its first edition of the Guidelines on controlled trials of drugs in episodic migraine because only quality trials can form the basis for international collaboration on drug therapy, and these Guidelines would 'improve the quality of controlled clinical trials in migraine'. With the current trend for large multinational trials, there is a need for increased awareness of methodological issues in clinical trials of drugs and other treatments for chronic migraine. These Guidelines are intended to assist in the design of well-controlled clinical trials of chronic migraine in adults, and do not apply to studies in children or adolescents.

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