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Obesity (Silver Spring). 2008 May;16(5):1039-44. doi: 10.1038/oby.2007.84. Epub 2008 Feb 21.

Relative contributions of adiposity and muscularity to physical function in community-dwelling older adults.

Author information

1
Department of Medicine, Division of Geriatric Medicine, University of Colorado Denver, Aurora, Colorado, USA. catherine.jankowski@uchsc.edu

Abstract

OBJECTIVE:

To determine the relative contributions of adiposity and muscularity to multi-dimensional performance-based and perceived physical function in older adults living independently.

METHODS AND PROCEDURES:

Data from 109 women and men, aged 60 or older, with low serum dehydroepiandrosterone (DHEA) sulfate levels were included in this cross-sectional analysis of baseline measures from a single-site, randomized, controlled trial of DHEA replacement therapy. Physical function was determined by means of performance on the 100-point Continuous Scale-Physical Functional Performance (CS-PFP) test and by self-reporting using the physical function subscale of the Medical Outcomes Short Form-36 (SF36PF). Body composition was measured by dual-energy X-ray absorptiometry (DXA). Linear regression analyses were used to determine the contributions of body mass index (BMI; kg body mass/m2), fat index (FI; kg fat/m2), and appendicular skeletal muscle index (ASMI; kg muscle/m2) to the CS-PFP and SF36PF scores, adjusted for age and sex.

RESULTS:

Age-adjusted regression analyses indicated that FI, but not ASMI, was a significant (P<0.001) determinant of CS-PFP (R2=0.54) and SF36PF (R2=0.37). When adjusted for age and sex, BMI was nearly as good a predictor of CS-PFP (R2=0.50) and SF36PF (R2=0.34) as FI.

DISCUSSION:

Adiposity was a stronger predictor of measured and self-reported physical function than was muscularity in older adults living independently. BMI, adjusted for sex, is a reasonable substitute for adiposity in the prediction of physical function.

Comment in

PMID:
18292753
PMCID:
PMC4391797
DOI:
10.1038/oby.2007.84
[Indexed for MEDLINE]
Free PMC Article
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