Format

Send to

Choose Destination
Fertil Steril. 2008 Aug;90(2):346-51. doi: 10.1016/j.fertnstert.2007.06.046. Epub 2008 Feb 21.

Diminished paternity and gonadal function with increasing obesity in men.

Author information

1
Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. epauli@hmc.psu.edu

Abstract

OBJECTIVE:

To examine the relationship of male obesity and reproductive function.

DESIGN:

Observational study.

SETTING:

Academic medical center.

PATIENT(S):

Eighty-seven adult men, body mass index (BMI) range from 16.1 to 47.0 kg/m(2) (mean = 29.3 kg/m(2); SD = 6.5 kg/m(2)).

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Reproductive history, physical examination, inhibin B, FSH, LH, T, and unbound T levels, and semen analysis.

RESULT(S):

Body mass index was negatively correlated with testosterone (r = -0.38), FSH (r = -0.22), and inhibin B levels (r = -0.21) and was positively correlated with E(2) levels (r = 0.34). Testosterone also negatively correlated with skinfold thickness (r = -0.30). There was no correlation of BMI or skinfold thickness with semen analysis parameters (sperm density, volume, motility, or morphology). Inhibin B level correlated significantly with sperm motility (r = 0.23). Men with paternity had lower BMIs (28.0 kg/m(2) vs. 31.6 kg/m(2)) and lower skinfold thickness (24.7 mm vs. 34.1 mm) than men without.

CONCLUSION(S):

Obesity is an infertility factor in otherwise normal men. Obese men demonstrate a relative hypogonadotropic hypogonadism. Reduced inhibin B levels and diminished paternity suggest compromised reproductive capacity in this population.

PMID:
18291378
PMCID:
PMC2597471
DOI:
10.1016/j.fertnstert.2007.06.046
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center