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Mol Immunol. 2008 May;45(9):2715-20. doi: 10.1016/j.molimm.2008.01.004. Epub 2008 Mar 4.

A common idiotype in IgE and its relation to recognition of the grass pollen allergen Phl p 2.

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1
Department of Immunotechnology, Lund University, BMC D13, SE-221 84 Lund, Sweden.

Abstract

The variable regions of allergen-specific IgE, the isotype mediating allergic responses, are poorly defined to date. In this study we define the character of human antibody binding sites recognizing Phl p 2, a major allergen from timothy grass pollen. Independently raised specificities developed by phage display technology tended to have common sequence motifs (idiotypes), such as IGHV4-31 germline gene origin and heavy chain complementarity-determining region (CDR) 3 length and sequence. They also combined with highly related light chain sequences. Such heavy chain variable domain-encoding transcripts have also been found in the IgE-encoding transcriptome of yet other grass pollen allergic subjects. Altogether these data argue that a common idiotype is used to establish specific antibodies with a potential to mediate allergic responses to Phl p 2. Such a restriction may contribute to the limited molecular diversity observed in some IgE populations.

PMID:
18289681
DOI:
10.1016/j.molimm.2008.01.004
[Indexed for MEDLINE]
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