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J Vet Intern Med. 2008 Jan-Feb;22(1):120-8. doi: 10.1111/j.1939-1676.2007.0008.x.

Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease.

Author information

1
Department Patologia Animale, Faculty Veterinary Medicine, Grugliasco, Italy. mborgare@vet.k-state.edu

Abstract

BACKGROUND:

There are few studies evaluating the natural history and prognostic variables in chronic mitral valve disease (CMVI) in a heterogeneous population of dogs.

OBJECTIVES:

To estimate survival and prognostic value of clinical and echocardiographic variables in dogs with CMVI of varying severity. Five hundred and fifty-eight dogs belonging to 36 breeds were studied.

METHODS:

Dogs were included after clinical examination and echocardiography. Long-term outcome was assessed by telephone interview with the owner.

RESULTS:

The mean follow-up time was 22.7 +/- 13.6 months, and the median survival time was 19.5 +/- 13.2 months. In univariate analysis, age>8 years, syncope, HR>140 bpm, dyspnea, arrhythmias, class of heart failure (International Small Animal Cardiac Health Council), furosemide therapy, end-systolic volume-index (ESV-I)>30 mL/m(2), left atrial to aortic root ratio (LA/Ao)>1.7, E wave transmitral peak velocity (Emax)>1.2 m/s, and bilateral mitral valve leaflet engagement were associated with survival time when all causes of death were included. For the cardiac-related deaths, all the previous variables except dyspnea and EDV-I>100 mL/m(2) were significantly associated with survival time. Significant variables in multivariate analysis (all causes of death) were syncope, LA/Ao>1.7 m/s, and Emax>1.2 m/s. For cardiac-related death, the only significant variable was LA/Ao>1.7.

CONCLUSIONS AND CLINICAL IMPORTANCE:

Mild CMVI is a relatively benign condition in dogs. However, some clinical variables can identify dogs at a higher risk of death; these variables might be useful to identify individuals that need more frequent monitoring or therapeutic intervention.

PMID:
18289298
DOI:
10.1111/j.1939-1676.2007.0008.x
[Indexed for MEDLINE]
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