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Curr Top Med Chem. 2008;8(2):101-13.

Pyranose N-glycosyl amines: emerging targets with diverse biological potential.

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Department of Chemistry, Youngstown State University, 1 University Plaza, Youngstown, OH 44555, USA.


Interest in the chemistry and biological properties of non-nucleoside N-glycosidic compounds has gathered pace over the past several years; the occurrence of the N-glycoside moiety in glycoproteins and a range of active natural products has prompted the synthesis of a diverse spectrum of related materials with promising potential in medicinal chemistry. Particularly prominent has been the synthesis of novel N-glycosyl amides, 1,2,3-triazoles, and progress in the construction and diversification of natural products such as the mannopeptimycins and indolocarbazoles, each of which are discussed in this article.

[Indexed for MEDLINE]

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