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Curr Pharm Des. 2008;14(4):338-51.

Apolipoprotein E knockout models.

Author information

1
Onassis Cardiac Surgery Center, 356 Sygrou Ave 176 74 Athens, Greece. genovefa@kolovou.com

Abstract

Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time. The current review considers lipid metabolism and inflammation as well as nutritional and pharmacological agents affecting atherosclerosis, using the apo E knock out mouse model.

PMID:
18289060
DOI:
10.2174/138161208783497769
[Indexed for MEDLINE]

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