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Curr Pharm Biotechnol. 2007 Dec;8(6):337-43.

RNAi screening for therapeutic targets in human malignancies.

Author information

1
Department of Biomedicine, University of Bergen, Bergen, Norway.

Abstract

The advent of RNA interference (RNAi) based library screening approaches has sparked a surge in loss-of-function genetic screens. Several recent screens have aimed to identify novel regulators of cancer-related phenotypes. These employ various tumor cell types to model malignant cell functions and use different RNAi effector library approaches to reveal a cache of novel tumor regulators. This review surveys recent RNAi screens conducted in transformed human cells.

PMID:
18289042
DOI:
10.2174/138920107783018426
[Indexed for MEDLINE]

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