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Prostate. 2008 May 1;68(6):675-8. doi: 10.1002/pros.20729.

Analysis of the gene coding for the BRCA2-interacting protein PALB2 in hereditary prostate cancer.

Author information

1
Program in Cancer Genetics, Department of Oncology, McGill University, Montréal, QC, Canada.

Abstract

BACKGROUND:

The genetic basis of susceptibility to prostate cancer (PRCA) remains elusive. Mutations in BRCA2 have been associated with increased prostate cancer risk and account for around 2% of young onset (<56 years) prostate cancer cases. PALB2 is a recently identified breast cancer susceptibility gene whose protein is closely associated with BRCA2 and is essential for BRCA2 anchorage to nuclear structures. This functional relationship made PALB2 a candidate PRCA susceptibility gene.

METHODS:

We sequenced PALB2 in probands from 95 PRCA families, 77 of which had two or more cases of early onset PRCA (age at diagnosis <55 years), and the remaining 18 had one case of early onset PRCA and five or more total cases of PRCA.

RESULTS:

Two previously unreported variants, K18R and V925L were identified, neither of which is in a known PALB2 functional domain and both of which are unlikely to be pathogenic. No truncating mutations were identified.

CONCLUSIONS:

These results indicate that deleterious PALB2 mutations are unlikely to play a significant role in hereditary prostate cancer.

PMID:
18288683
PMCID:
PMC2683627
DOI:
10.1002/pros.20729
[Indexed for MEDLINE]
Free PMC Article
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