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Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3112-6. doi: 10.1073/pnas.0712180105. Epub 2008 Feb 14.

WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines.

Author information

1
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

Abstract

Mitochondrial fission and trafficking to dendritic protrusions have been implicated in dendritic spine development. Here, we show that Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous protein 1 (WAVE1) controls depolarization-induced mitochondrial movement into dendritic spines and filopodia and regulates spine morphogenesis. Depolarization-induced degradation of the p35 regulatory subunit of cyclin-dependent kinase 5 (Cdk5), with the resultant decreased inhibitory phosphorylation on WAVE1, depend on NMDA receptor activation. Thus, WAVE1 dephosphorylation and activation are likely associated with mitochondrial redistribution and spine morphogenesis.

PMID:
18287015
PMCID:
PMC2268593
DOI:
10.1073/pnas.0712180105
[Indexed for MEDLINE]
Free PMC Article

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