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Pediatr Pulmonol. 2008 Apr;43(4):391-5. doi: 10.1002/ppul.20793.

IL-10 gene polymorphism at -1082 A/G is associated with severe rhinovirus bronchiolitis in infants.

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Paediatric Research Centre, Tampere University and University Hospital, Tampere, Finland.


We analyzed polymorphisms of IL-10 -1082 G/A, IL-18 -137 G/C, TLR4 +896 A/G, and IFNG +874 T/A in 139 infants under 6 months of age hospitalized with bronchiolitis and 400 unselected blood donors. Causative viruses were determined by PCR. Infants with bronchiolitis associated with a virus other than respiratory syncytial virus (N = 18), were more often IL-10 -1082 allele G non-carriers, that is, homozygous for allele A (AA) than controls (66.7% vs. 28.0%, P < 0.0001). Infants with RSV bronchiolitis did not differ from controls. This finding suggests a different pathogenic mechanism for RSV bronchiolitis as compared with wheezing associated with other viral infections, for example, rhinovirus in infants under 6 months of age.

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