Format

Send to

Choose Destination
Head Neck. 2008 Jun;30(6):743-9. doi: 10.1002/hed.20779.

Pilot study: volatile organic compounds as a diagnostic marker for head and neck tumors.

Author information

1
Department of Otolaryngology, Innsbruck Medical University, Innsbruck, Austria. joachim.schmutzhard@i-med.ac.at

Abstract

BACKGROUND:

In the last decade, the analysis of volatile organic compounds (VOC) has undergone a rapid development. In this pilot study, patients with HNSCC were tested with a proton transfer reaction-mass spectrometry in order to establish a minimal invasive screening method.

METHODS:

Overall in a period of 2 years, 22 carcinoma patients were recruited for the study. All patients had a newly diagnosed histologically secured squamous cell carcinoma of the upper aerodigestive tract. These results were statistically compared with 3 control groups: healthy controls, high-risk, and posttherapy patients.

RESULTS:

Two hundred nine different masses were measured; 188 of these were evaluated. The statistical workup of the 4 study groups produced 42 different masses, which showed a statistically significant difference from the carcinoma group compared with the control groups.

CONCLUSION:

A screening method for HNSCC using VOC seems to be possible, but further investigation is necessary.

PMID:
18286484
DOI:
10.1002/hed.20779
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center