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EMBO J. 2008 Feb 20;27(4):581-8. doi: 10.1038/emboj.2008.11.

Quality control of DNA break metabolism: in the 'end', it's a good thing.

Author information

1
Department of Cell Biology and Genetics, Erasmus Medical Center, Rotterdam, The Netherlands. r.kanaar@erasmusmc.nl

Abstract

DNA ends pose specific problems in the control of genetic information quality. Ends of broken DNA need to be rejoined to avoid genome rearrangements, whereas natural DNA ends of linear chromosomes, telomeres, need to be stable and hidden from the DNA damage response. Efficient DNA end metabolism, either at induced DNA breaks or telomeres, does not result from the machine-like precision of molecular reactions, but rather from messier, more stochastic processes. The necessary molecular interactions are dynamically unstable, with constructive and destructive processes occurring in competition. In the end, quality control comes from the constant building up and tearing down of inappropriate, but also appropriate reaction steps in combination with factors that only slightly shift the equilibrium to eventually favour appropriate events. Thus, paradoxically, enzymes antagonizing DNA end metabolism help to ensure that genome maintenance becomes a robust process.

PMID:
18285819
PMCID:
PMC2262039
DOI:
10.1038/emboj.2008.11
[Indexed for MEDLINE]
Free PMC Article

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