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Nat Rev Mol Cell Biol. 2008 Apr;9(4):297-308. doi: 10.1038/nrm2351. Epub 2008 Feb 20.

Regulation of DNA repair throughout the cell cycle.

Author information

1
FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy. dana.branzei@ifom-ieo-campus.it.

Abstract

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.

PMID:
18285803
DOI:
10.1038/nrm2351
[Indexed for MEDLINE]

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