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Arch Dis Child Fetal Neonatal Ed. 2008 Jul;93(4):F307-9. doi: 10.1136/adc.2007.130880. Epub 2008 Feb 19.

Predicting significant hyperbilirubinaemia using birth weight.

Author information

1
Division of General Pediatrics, University of California, San Francisco, California, USA. FlahermanV@peds.ucsf.edu

Abstract

BACKGROUND:

A recent study proposed a risk factor scoring system for prediction of hyperbilirubinaemia that assigned increased risk to infants of higher birth weight.

OBJECTIVE:

To investigate this novel finding in a large, retrospective cohort analysis.

METHODS:

105 384 newborns (> or =2000 g and > or =36 weeks) were analysed, and the effect of higher birth weight on total serum bilirubin (TSB) > or =342 micromol/l was reported using logistic regression to control for gestational age, scalp injury diagnosis, maternal diabetes, method of delivery and other confounders.

RESULTS:

The odds ratio for the effect of an additional 500 g of birth weight on TSB > or =342 micromol/l declined with increasing gestational age from 1.55 (95% CI 1.28 to 1.87) at 36 weeks to 1.30 (95% CI 1.12 to 1.50) at 37 weeks and 1.14 (95% CI 1.01 to 1.29) at 38 weeks. There was no association for infants > or =39 weeks.

CONCLUSION:

Higher birth weight predicts TSB > or =342 micromol/l in 36-38 week infants, but not in infants > or =39 weeks. Further research should explore the causal mechanism for the association in less-mature infants.

PMID:
18285376
DOI:
10.1136/adc.2007.130880
[Indexed for MEDLINE]

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