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J Oral Pathol Med. 2008 Jul;37(6):336-40. doi: 10.1111/j.1600-0714.2008.00646.x. Epub 2008 Feb 15.

Oral manifestations in patients with gastro-oesophageal reflux disease: a single-center case-control study.

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Department of Oral Sciences, Faculty of Medicine, School of Dentistry, Oral Medicine Section, University of Palermo, Palermo, Italy.



To assess the occurrence of oral pathological changes and symptoms in patients affected by gastro-oesophageal reflux disease (GERD).


200 patients with GERD and 100 matched healthy controls were studied. Thorough visual examination of the dental and oral mucosal tissues was performed and medical history relevant to oral symptoms was collected. The primary outcome was defined as a statistically significant difference, between the study group and controls, in the presence of the following indicators: soft/hard palate and uvula erythema, tooth wear, xerostomia, oral acid/burning sensation, subjective halitosis and dental sensitivity. Statistical analysis included chi-squared test, and crude odds ratio with 95% CI.


Univariate analysis showed that xerostomia, oral acid/burning sensation, subjective halitosis, and soft and hard palate mucosa and uvula erythema were more common in patients with GERD than matched controls (P < 0.05).


This study failed to find any significant association between GERD and dental erosions, whereas some symptoms and other objective oral mucosal changes were found to be significantly associated with GERD.

[Indexed for MEDLINE]

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