Abstract
Combined application of mumps and measles vaccine strains in equal doses results in significant decrease of immune response to the former component in humans. It is possible that this phenomenon is related with well-known immunodepressive effect of measles virus, which was demonstrated both in vivo and in vitro. It was previously shown that myelopeptide-2 (MP-2) partially neutralizes suppressive effect of measles vaccine on blast transformation of activated human lymphocytes in vitro. Partial supression of immune response to mumps vaccine by live measles vaccine was reproduced in laboratory animals. It was shown that in experiment MP-2 partially neutralized suppressive effect of measles vaccine.
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Adjuvants, Immunologic / pharmacology*
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Animals
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Antibodies, Viral / blood
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Drug Evaluation, Preclinical
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Female
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Guinea Pigs
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Immunization Schedule
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Immunization*
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Immunosuppression Therapy
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Injections, Intramuscular
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Measles / blood
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Measles / immunology*
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Measles Vaccine / administration & dosage*
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Morbillivirus / immunology*
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Mumps / blood
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Mumps / immunology*
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Mumps Vaccine / administration & dosage*
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Mumps Vaccine / immunology*
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Mumps virus / immunology*
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Oligopeptides / administration & dosage
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Oligopeptides / pharmacology*
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Rats
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Vaccines, Combined / immunology
Substances
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Adjuvants, Immunologic
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Antibodies, Viral
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Measles Vaccine
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Mumps Vaccine
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Oligopeptides
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Vaccines, Combined
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myelopeptides