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Theor Popul Biol. 2008 May;73(3):369-73. doi: 10.1016/j.tpb.2007.11.011. Epub 2007 Dec 31.

The IBD process along four chromosomes.

Author information

1
Department of Statistics, University of Washington, Box 354322, Seattle, WA 98195, USA. eathomp@u.washington.edu

Abstract

In this note, we present the continuous-time Markov rate matrix that models identity by descent (ibd) patterns among four chromosomes in a population. The equilibrium distribution of this Markov process along a chromosome is the set of 4-gene state probabilities given by the Ewens sampling formula. This model will facilitate inference of identity by descent among the four chromosomes of a pair of individuals, using data at dense SNP loci among which there may be linkage disequilibrium.

PMID:
18282591
PMCID:
PMC2518088
DOI:
10.1016/j.tpb.2007.11.011
[Indexed for MEDLINE]
Free PMC Article

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