Format

Send to

Choose Destination
Adv Genet. 2008;61:175-205. doi: 10.1016/S0065-2660(07)00006-5.

Global control regions and regulatory landscapes in vertebrate development and evolution.

Author information

1
Developmental Biology Unit, EMBL, 69117 Heidelberg, Germany.

Abstract

During the course of evolution, many genes that control the development of metazoan body plans were co-opted to exert novel functions, along with the emergence or modification of structures. Gene amplification and/or changes in the cis-regulatory modules responsible for the transcriptional activity of these genes have certainly contributed in a major way to evolution of gene functions. In some cases, these processes led to the formation of groups of adjacent genes that appear to be controlled by both global and shared mechanisms.

PMID:
18282506
DOI:
10.1016/S0065-2660(07)00006-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center