Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Chem Biol. 2008 Feb;12(1):18-24. doi: 10.1016/j.cbpa.2008.01.021. Epub 2008 Mar 7.

Discovering mechanisms of signaling-mediated cysteine oxidation.

Author information

  • 1Department of Biochemistry, Center for Structural Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States. lbpoole@wfubmc.edu

Abstract

Accumulating evidence reveals hydrogen peroxide as a key player both as a damaging agent and, from emerging evidence over the past decade, as a second messenger in intracellular signaling. This rather mild oxidant acts upon downstream targets within signaling cascades to modulate the activity of a host of enzymes (e.g. phosphatases and kinases) and transcriptional regulators through chemoselective oxidation of cysteine residues. With the recent development of specific detection reagents for hydrogen peroxide and new chemical tools to detect the generation of the initial oxidation product, sulfenic acid, on reactive cysteines within target proteins, the scene is set to gain a better understanding of the mechanisms through which hydrogen peroxide acts as a second messenger in cell signaling.

PMID:
18282483
PMCID:
PMC2408887
DOI:
10.1016/j.cbpa.2008.01.021
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center