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FEBS Lett. 2008 Apr 9;582(8):1259-65. doi: 10.1016/j.febslet.2008.02.014. Epub 2008 Feb 20.

Towards a molecular characterisation of pathological pathways.

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Institute for Research in Biomedicine and Barcelona Supercomputing Center, c/Josep Samitier 1-5, 08028 Barcelona, Spain.


The dominant conceptual reductionism in drug discovery has resulted in many promising drug candidates to fail during the last clinical phases, mainly due to a lack of knowledge about the patho-physiological pathways they are acting on. Consequently, to increase the revenues of the drug discovery process, we need to improve our understanding of the molecular mechanisms underlying complex cellular processes and consider each potential drug target in its full biological context. Here, we review several strategies that combine computational and experimental techniques, and suggest a systems pathology approach that will ultimately lead to a better comprehension of the molecular bases of disease.

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