Send to

Choose Destination
See comment in PubMed Commons below
Biochemistry (Mosc). 2007 Dec;72(13):1422-38.

Noncoding RNAs and chromatin structure.

Author information

  • 1Institute of Molecular Genetics, Russian Academy of Sciences, pl. Kurchatova 2, 123182 Moscow, Russia.


A number of examples of noncoding RNA-connected chromatin modifications in eukaryotes has been recently revealed. Four cases are under detailed consideration in the present review, namely Xist RNA-dependent X-chromosome inactivation in mammals, roX RNA-dependent hyperactivation of X-chromosome in the fruit fly (in both cases the goal is dosage compensation, equalization of transcription level from two X chromosomes in females and one in males), and two examples of RNAi-connected down-regulation of transcription--siRNA-dependent heterochromatin formation in fission yeast and RdDM (RNA-dependent DNA methylation) in plants (FWA gene regulation in Arabidopsis). Although overall quite different, each phenomenon demonstrates some common features of RNA-driven chromatin modification process, including the role of RNA in aiming of chromatin-modifying protein complexes to their targets and subsequent formation of self-maintaining specific chromatin conformation (DNA methylation, changes in histone code, and binding of self-assembling protein complexes).

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Biochemistry (Moscow)
    Loading ...
    Write to the Help Desk